Saturday, April 8, 2017

The rat lung worm is a nematode parasite that has snails as an intermediate host and can infect humans as incidental hosts and cause a fatal brain disease


Climate denial by Trump and Scott Pruit, the head of the Environmental Protection Agency, is not only stupid, but could turn out to be very dangerous for human health.

Angiostrongylus cantonensis is a nematode that lives in the lungs of rats and has snails as intermediate hosts.  It is endemic in humans and can cause an often fatal brain disease that is untreatable. The rat disease was discovered in 1935 and is found world-wide, and the first human case of the disease was recorded in Taiwan in 1944.  Recently, human cases have been identified in Hawaii, California, Alabama, Louisiana, Florida, and along the Gulf Coast. “It is a worm infection introduced into North America through globalization,” said Peter Hotez, the dean of the National School of Tropical Medicine at Baylor College of Medicine. Transmission to humans occurs when people eat the intermediate hosts, which may even not be detectable on a leaf of lettuce that wasn’t washed. Even the slime left by an infected slug could transmit the disease and eating raw freshwater prawns, crabs, and frogs is also dangerous. In Maui there were six cases in a three month period.  The infected rats defecate worm larvae that are then eaten by snails, slugs and shrimp.  Humans are infected by eating contaminated food or even directly from handling infected snails. The parasites migrate to the brain meninges and can even penetrate into the brain. The disease is very difficult to diagnose.  Even though humans are not a true host, the presence of the worms causes a meningitis with severe headache, tremors, pain and inflammation caused by death of the worms and the host immune response. In fact, treatment with drugs used against other worm parasites can exacerbate the disease by killing the parasites and increasing inflammation.  

The rapid increase in the range of these parasites is almost certainly caused by climate change and globalization. There is an excellent recent paper entitled Geographic Range Expansion for Rat Lungworm in North America in Emerging Infectious Diseases (Volume 21, Number 7—July 2015) by Emily M. York, James P. Creecy, Wayne D. Lord, and William Caire.

Unfortunately, we are in the era of the fake-President Donald Trump, a climate denier, who is proposing a 30% decrease in the EPA budget. In fact, EPA workers are not allowed to even mention the term “climate change”. That reminds me of the king who once demanded that the ocean waves stop. I just hope that the FBI finishes its investigation and Trump and his crowd are indicted for treason and prosecuted. It should prove difficult for Trump to do more damage to our country when he is in jail.

But also unfortunately, this will certainly prove to be one of the least problems caused by climate change, and will pale in relation to the financial and ecological disasters caused by the rise in ocean level which will submerge major coastal cities worldwide, the expected mass migrations of people affected by the losses of water and food, and by the possibly nuclear wars caused by these migrations. In fact I doubt that our civilization will survive this tremendous damage to its infrastructure. 

Ah well, I have no children to suffer, but I am sure that the politicians such as Trump and the Republicans have children and grandchildren who will wonder why their ancestors let this happen to our world!

Monday, March 27, 2017

Republican talking Points and Fake News



There is a Fake News Republican talking point that Obamacare is in a “death spiral”. Unfortunately for their talking point, Obamacare is doing quite well, thank you.  Another talking point especially by the Lier in Chief, Donald Trump, was the repeated calling of Hilary especially in the debates, “crooked Hilary”. If  fake news is repeated enough times, it becomes a fact , whereas it is merely a “walking zombie”.  Reince Priebus said that Obama’s health care reform law is “imploding and exploding”. Speaker Paul Ryan  said many times that the ACA is in a “death spiral” and that “the law is collapsing”. Trump said that the ACA is “just about ready to implode” and “Obamacare is dead.”. He also said the immoral hope that after the failure of the new Republican Health Care law, Obamacare will collapse and he will pick up the pieces.

The CBO recently found that the health insurance “market would probably be stable in most areas.  And the New York Times pointed out that the healthcare market under Obamacare would probably be stable.  The death spiral lie was started when Aetna pulled out of 11 states and the CEO blamed this on a “death spiral”. This was actually done because Aetna was not allowed to merge with Humana and to avoid antitrust scrutiny. Another argument against a death spiral is that fewer young adults, who usually are more healthy, would buy policies through the exchanges, but in fact 85% of  the new policy members are protected from premium increases by subsidies. In 2017, 121.2 million people were signed up on Obamacare. There probably would have been more except that Trump stopped funding government adds reminding people of the deadlines for enrollment. The number will increase since four states people who started the enrollment before Jan. 31 to be enrolled. And Louisiana recently expanded Medicaid.  Experts agree that Obamacare would probably stabilize in the next few years. However, there are a few states where the markets are near collapse, but in Wisconsin, Idaho, Massachusetts, New Mexico, Arkansas and California, the markets have multiple insurance companies. New York has 17 insurance carriers and total enrollments increased 28% for 2017. Also fake news is that doctors are leaving due to Obamacare. But the total number of active physicians has increased 8% from 2010 and medical school applicants and students are at an all-time high. Finally the Medicaid expansion covers around 11 million people and has driven down the uninsured rate by around 7%.

There are definitely some problems in Obamacare, but most are due to Republican governors refusing to expand Medicare.  And a recent Trump executive order instructed agencies to relax Healthcare rules, and the IRS complied by refusing to enforce the individual mandate.


In 1897, the American writer, Mark Twain, said that “the report of my death was an exaggeration”. If the Republicans want Obamacare to die, they will have to do it themselves, which they are quite willing and capable of doing.  The only saving feature is that current users of Obamacare and Medicaid (Democrats and Republicans) have been filling the town hall meetings of their Congressmen and shouting down any signs of wanting to destroy Obamacare. This is something that Trump and friends can think about in their jail cells. The fact is that only the thing that is in a “death spiral” is the Republican Party. 

Friday, February 3, 2017

Too Good to be True?

A paper came out in Nature recently with the mind-numbing  title: “The antibody aducanumab reduces Aplaques in Alzheimer’s disease.” But in perusal of the Abstract a statement jumped out to me: “In a transgenic mouse model of Alzheimer’s Disease (AD) aducanumab is shown to enter the brain, bind parenchymal Ab, and reduce soluble and insoluble Ain a dose-dependent manner. In patients with prodromal or mild Ab, one year of monthly intravenous infusions of aducanumab reduces brain Ab in a dose-and time-dependent manner. This is accompanied by a slowing of clinical decline measured by Clinical Dementia Ratings-Sum of Boxes and Mini Mental State Examination scores.” They concluded that “..these results justify further development of aducanumab for the  treatment of AD.”

Now, I am not in the AD-amyloid field, but this appears very exciting. I know very well that there has been a great controversy whether amyloid-plaques and tangles have anything directly to do with the clinical development of AD, but these data show that this antibody reduces brain Ab plaques. It also provides preliminary evidence for an effect on the clinical development of AZ.


But before you run out and tell your mother about this, a larger Phase 3 clinical study with many more patients must be performed, but it already gives me a warm and fuzzy feeling. 

Wednesday, January 25, 2017

Computer viruses

I had written a blog entry recently about the possibility that the Kaspersky Antivirus Company could be involved with the Russian hacking of our election, but I never posted it, just in case it was wrong. The reason I thought that this was a possibility is that I had read that the CEO, Eugene Kaspersky, was a close friend of Putin. In addition, Kaspersky was the first company to forensically uncover the Stuxnet worm and its progeny, Duqu 2.0, that attacked the Iranian nuclear program as well as the entire Kaspersky computer network. This worm was presumably created by the NSA and the Israeli intelligence agencies.

So it was no great surprise that I read today that Ruslan Stoyanov, the Kaspersky Manager in charge of investigating computer hacking, was arrested in Russia and charged with Treason!  However, in view of all the recent publicity about Russian computer hacking, this has the definite smell of disinformation.

More to come, I presume.
  

Saturday, December 10, 2016

Just Saying


I copy below a Reuters News item that just appeared recently:

Staffers at the Department of Energy say President-elect Donald Trump’s transition team is seeking a list of employees who have worked to cut carbon emissions, a move many fear means an impending purge of those fighting climate change. A report by ABC News late Friday said staffers had received a 74-point memo on Tuesday asking for information on several of the department’s programs, as well as a list of names of staffers who worked on certain projects. One question specifically asks for the names of those who attended international conferences on climate change. “It looks like Trump and his administration are planning a political witch hunt which has no place in American government: purging or marginalizing anyone who has worked on the issue of climate change,” John Coequyt, climate policy director at the Sierra Club, said in a statement on Friday. Trump has repeatedly described climate change as a hoax created by the Chinese. His choice of Scott Pruitt, a climate change denier, to head the Environmental Protection Agency has further fueled fears that the Trump administration will undo all progress made fighting global warming by the Obama administration.

Let me remind you of a time in the 1930’s when similar lists of names were also acquired in Germany. 
In May 1935, Jews were forbidden to join the Armed Forces, and that year anti-Jewish propaganda appeared in Nazi German shops and restaurants. The Nuremberg Laws were passed around the time of the Nazi rallies at Nuremberg; On September 15, 1935, the Law for the Protection of German Blood and Honor was passed, preventing sexual relations and marriages between Aryans and Jews. At the same time the Reich Citizenship Law was passed and was reinforced in November by a decree, stating that all Jews, even quarter- and half-Jews, were no longer citizens of their own country. This meant that they had no basic civil rights, such as that to vote. In 1936, Jews were banned from all professional jobs, effectively preventing them from exerting any influence in education, politics, higher education and industry. Because of this, there was nothing to stop the anti-Jewish actions which spread across the Nazi-German economy. As of March 1, 1938, government contracts could no longer be awarded to Jewish businesses. On September 30, "Aryan" doctors could only treat "Aryan" patients. Provision of medical care to Jews was already hampered by the fact that Jews were banned from being doctors or having any professional jobs. Beginning August 17, 1938, Jews with first names of non-Jewish origin had to add Israel (males) or Sarah (females) to their names, and a large J was to be imprinted on their passports beginning October 5. On November 15 Jewish children were banned from going to normal schools. By April 1939, nearly all Jewish companies had either collapsed under financial pressure and declining profits, or had been forced to sell out to the Nazi German government. 
All of these actions required lists of names and addresses of Jewish people. 

Just saying....

Wednesday, November 9, 2016

Shock and Despair


After the initial shock and subsequent despair for this country, I gave some thought to why this  happened. Poor Hillary, she did not deserve this. It does show that if lies are repeated enough times, people start to believe them. She has had this all her political life. And then came the Trump  madman. His calling her "crooked Hillary"  again and again without any evidence then led to his saying in a debate not only that she should be in jail but that, as President, he himself would have his Attorney General find her guilty (of what?). It is ironic that he himself was 100 times more guilty of everything and more that he accused her of. 

OK, but then she was still on the road to winning easily, but the anti-Hillary conspiracy began to really gel. First there was the hacking of her emails by the Russians and the slow feeding of Julian's Wikileaks monster to leak the hacked emails slowly to the press, with madman Trump actually asking the Russians to find her "missing" emails. And it is highly likely that  the Russian masters of these hackers made subtle modifications of selected emails. But amazingly Hillary was still leading in all polls. Then came the coup de Gras in the form of the FBI Director, James Comey. What he did can best be explained by copying a Newsweek essay by Kurt Eichenwald:

James Comey should not simply be fired as director of the Federal Bureau of Investigation. He must be barred forever from any form of public service. In the last 10 days, Comey has whipsawed the election for president of the United States. Now we know he did it for no reason. When his agents found information that suggested there were emails on a laptop that might have relevance to the investigation of Hillary Clinton and her email servers, Comey did not wait until he knew even a scintilla of information before announcing it to the world. Reasonably, lots of voters assumed there must be a there there—who could imagine a person with the power of the FBI director would turn the election on its head for no particular reason, on the basis of nothing?
Then, Sunday, Comey handed down another missive from on high: Never mind. His agents had looked through the emails and decided they were piffle. His majesty, the FBI director, has not yet deigned to officially inform his subjects—the American people—whether the emails related to the Clinton case or what they were. (However, people involved in the case tell Newsweek that almost all of them were duplicates of what the bureau already had or were personal.) He just said “nothing to see here” and waived us on our way.
Well, forget it, Jim. We’re not moving on. America has just witnessed one of the most—if not the most—egregious abuses of power in the service of one man’s ego in its history. Joseph McCarthy and A. Mitchell Palmer at least believed they were fighting a Communist threat. Richard Nixon, in Watergate, at least had the motive of retaining power and covering up wrongdoing. But Comey—who I do not believe did this for partisan reasons—has no such motive. This was about him, about preserving his now forever-destroyed reputation, about preening with his self-satisfied standing as a maverick who acts based on what he thinks is right, regardless of others’ opinion. But there is a very thin line between being independent and being reckless. And Comey has demonstrated he does not know the difference.
Before launching into a full Comey tear-down, a few facts must be understood. The FBI is an investigative arm of the Department of Justice. Nothing more, nothing less. An extremely small minority are lawyers, or even have basic legal training. They do not—thank God—decide who gets indicted and who doesn’t. Prosecutors run criminal cases and direct the agents. As many prosecutors have told me over the years, there is almost never an instance where agents who have been investigating a case for months do not recommend for prosecution. Tunnel vision is one reason; the fact that agents rise in the ranks by delivering cases that lead to prosecution is another. That is why prosecutors—and through them, grand juries—make the decision to charge or not. They both serve as a backstop to agents who don’t know the law and have no ability to objectively review their own evidence.
This is why all this nonsense pushed by the Fox Newses of the world has been so deceptive: Screaming “the agents wanted to indict” is on par with “the fish wants to swim.” More important—if any agents really did say these things—they are unfit for the bureau; they must be found and fired immediately for this separate abuse of power.
What that means is, if the FBI does not even conclude it has enough evidence to write a memo recommending prosecution to the Justice Department, there is simply nothing there. Assuming someone committed a crime when the FBI concludes the evidence obtained in the investigation is not worth turning over to prosecutors is like assuming it must be raining when the skies are clear.
The FBI is never supposed to comment on ongoing investigations and, except in exceptional circumstances, never disclose whether it has or has not recommended prosecution. Instead, on indictment, prosecutors stand up at a press conference, announce the charges, then thank the agents and offices of the FBI who conducted the investigation. If the bureau does not develop enough evidence to merit even a recommendation for prosecution, in those exceptional circumstances where it says anything, those are the words officials use: We have not developed evidence that merits a recommendation for prosecution.
In the last few months, unfortunately, Comey has demonstrated he understands none of this. He has broken these rules time and again, leaving himself in the position where he decided he had to break them a couple of more times. He has acted with a lack of accountability that has not been seen since J. Edgar Hoover held the post. It is unforgivable.
Comey came into the job as FBI director having been a federal prosecutor and the deputy attorney general in the George W. Bush administration. As anyone who has met him knows, he prizes his reputation for integrity and as one who rises above politics. In fact, he prizes it a little too much. And that is what even his allies in government are saying led to his disastrous decisions in recent months. Like Icarus, driven by hubris, he chose to fly too close to the sun and now has fallen into a sea of near-universal public contempt.
The signs of Comey’s coming downfall showed up quickly. In fact, the event that led to his golden reputation as a man of integrity, when viewed through in the context of everything Comey has done in his time as FBI director, looks quite different. He was cheered when the public learned that, while in the role of acting attorney general at a time when his boss, John Ashcroft, was in the hospital, he refused to sign a document authorizing the continuation of a warrantless wiretapping program used as part of the Bush administration’s counterterrorism efforts. Lots of drama surrounded the event, with Comey—in his later retelling of the story to Congress—as the hero. But in truth, by behaving as if only he knew the truth of the law, Comey burnished his reputation but changed nothing. A couple of fixes were made to the program, and he signed the authorization later.
Plenty of people in Washington knew of Comey’s self-infatuation and predicted it would lead to the exact kind of problem born of his arrogance that has convulsed the country for more than a week. In fact, shortly after he was nominated for FBI director, the Daily Beast quoted an unidentified Justice Department official saying these frighteningly prescient words: “If past is prologue, something will happen in the context of a legal, policy, or operational disagreement where Jim may get on the high horse and threaten to resign or take some other action unless things go the way he believes they should.” When he wanted to issue the now-famous first letter, the attorney general and everyone else consulted in the Justice Department said it was against policy and advised him not to do it. But Comey ignored everyone.
That’s the way it has been throughout Comey’s tenure at FBI. When the Obama administration adopted a policy of cutting down on mandatory minimum sentences, Comey stepped up to the microphones to declare the president wrong. Such sentences, he proclaimed, are helpful in developing cooperating witnesses. (In fact, there is no evidence to support Comey’s statement—mandatory minimums do nothing to persuade potential witnesses to cooperate. He just said it because he thought it was true.)
That was the same standard he used later in talking what was called the “Ferguson effect,” a term used to describe the idea that subjecting police to greater oversight and scrutiny increases the chance that they will be murdered. Not only is there no evidence supporting the idea, it has been thoroughly disproven. Yet Comey advances the idea as gospel based again on nothing but his personal beliefs. He was even urged to stop at a White House meeting, but as always, Comey felt certain he knew best, and continued spewing this falsehood.
Then came the time when the FBI needed to gain access to an iPhone that belonged to the extremists who committed an attack in San Bernardino, California, in 2015. Comey was told that an administration-wide encryption program was under development that would be harmed if he pushed Apple. He ignored the White House and the Pentagon and, in an action that thwarted the government encryption effort, demanded that Apple be forced to unlock the phone.
Time and again, Comey did what Comey wanted to do—regardless of the advice, regardless of what others thought, regardless of whether his arguments had no evidence supporting them. This all came to a head, though, with the investigation of Clinton’s use of a personal email server.
When the FBI concluded its investigation with the decision not to recommend charges, that was all any professional in the position of FBI director would say. There are many reasons for that—primarily, that is the extent of the bureau’s job. It is not an arbiter of morality or competence. More important, if the bureau goes further, both the powerful and powerless are in no position to argue the facts. A sentence that starts with the words “The FBI says…” is almost sacrosanct because of its history in the last number of decades of self-control.
Comey did none of these things. Instead, in an action that horrified many officials who have worked in Republican and Democratic administrations, Comey held a press conference where he blathered on and on about his personal opinions and presented details—sometimes incorrectly—about the investigation. He consulted with none of his colleagues, not even the attorney general. And while he proclaimed he would not be recommending prosecution, he excoriated Clinton for her use of the private email server—a statement that was totally beyond his role. He later told Congress that no prosecutor could ever make a case against her based on the evidence—words that should have cheered Clinton partisans, but which again were horrific. Comey does not speak for prosecutors. The arrogance reflected in that one statement was astonishing.
Then, Comey went further. He opened up the Clinton investigative files and had them posted online. This act was again unprecedented, unnecessary and unexplained. Put simply, Comey was out of control. He was acting under all his own rules—calling press conferences, absolving Clinton, condemning her, speaking for prosecutors, dumping FBI files online—and seemed to be making them up as he went along.
His recklessness opened him up to even more criticism from Republicans. Had he simply made the usual statement about no referral, there would have been nothing else to review. But with his endless proclamations and document dumps, he opened himself and the FBI for more criticism as people with no training in investigations or law—but plenty of interest in politicizing the FBI—picked through everything he said and every scrap of paper to scream that the only reason Clinton wasn’t indicted was because of politics. So much information had been placed in the public record by Comey that no one in the public could tell what was a manipulation of the facts and what was real.
Of course, despite all the outcry, Comey did not consider the possibility he had made a mistake. In a message to his employees in September, first reported by CNN, Comey tersely proclaimed that Jim Comey had been right about everything, if he did say so himself. “I’m OK if folks have a different view of the investigation (although I struggle to see how they actually could, especially when they didn’t do the investigation), or about the wisdom of announcing it as we did (although even with hindsight I think that was the best course),” Comey wrote.
Then came late October. Agents had been investigating allegation that former Congressman Anthony Weiner sent illicit, sexual text messages to an underage girl in North Carolina. As part of the inquiry, those agents seized a laptop and eventually discovered emails on it potentially related to the Clinton case. (Huma Abedin, a senior Clinton aide, is the estranged wife of Weiner, and it is her emails that were found on his laptop.) About a week after they had obtained the device, the agents told Comey about their find late on Thursday, October 27.
The emails had not been reviewed. No one reached out to either Weiner or Abedin to obtain permission to review them. No one tried to get a warrant. Literally, the bureau knew next to nothing. But still, the day after he was briefed, with no further information, Comey sent his letter announcing the non-development to Congress. The letter was vague and almost incomprehensible, leaving it to the politicians and reporters to fill in the blanks.
With Democrats reeling and Republicans declaring the announcement as proof that Clinton was about to be indicted, calls came from every side of the political spectrum that he provide more information. But once again, Comey stood firm, telling his employees at the FBI that—shock of shocks—he was right and everyone else was wrong. “There is a significant risk of being misunderstood,” Comey told the bureau employees in the communication, explaining why he was so vague in his letter to Congress. “It would be misleading to the American people were we not to supplement the record. At the same time, however, given that we don’t know the significance of this newly discovered collection of emails, I don’t want to create a misleading impression.”
Please. As any fifth grader not suffering under the weight of Comey’s ego could know immediately, saying next to nothing created a tremendously misleading impression. The numbers tell the ugly story. According to the prime political statistics site, FiveThirtyEight, Clinton’s probability of victory collapsed in the aftermath of Comey’s letter, falling from 85 percent to 65 percent in just a few days. Polls in Senate races changed. And throughout Comey’s week of silence, millions of people cast their votes. I personally know several people who changed their votes because of Comey’s letter—some to Trump but some to Clinton because they thought Comey was engaged in Hoover-like corruption of the FBI.
A huge swath of the public now thinks the FBI is a completely political organization: A large number of Democrats, because of the original letter followed by a week’s worth of leaks from other agents about other investigations, are convinced that the bureau is manipulating the election for the Republicans and cannot be trusted. Meanwhile, plenty of Republicans are arguing that Comey’s newest findings can’t possibly be true and that he caved to pressure from the Democrats. In other words, no matter what side of the political spectrum anyone is on, they agree that the FBI is political.
It’s not. Unfortunately, though, it is led by a man who finally outsmarted himself with his own arrogance. He has done more damage to the reputation of the FBI than any director since the Nixon administration. Comey will, without doubt, be listed as second only to Hoover as the worst director to ever hold the office because of his willingness to abuse his power.
Fixing the damage Comey inflicted on the FBI will take a long time. So long as a man is in charge who thinks he’s always right and cares more his personal reputation than his duty, the repairs cannot begin. Comey must be fired. But let’s wait until November 9.

Well, today is November 9, the worst has happened and now Comey will most likely never be even reprimanded  by the Tea Party Republicans still in power in the House and Senate. In fact he will probably be promoted by the presumptive new Attorney General, Rudi Guliani. Sad and horrifying at the same time.


Saturday, October 8, 2016

A Double-Wow Discovery



I rate science discoveries by the “wow” scale and I feel that this is at least a “double wow” discovery.

A second earth-like exoplanet has been discovered only four light years away (25 trillion miles), which is one of the closest star systems to earth. The planet is in an 11 day orbit around the red dwarf star, Proxima Centauri b. The mass of this planet is around 1.3 times that of earth and the planet appears  to be rocky. Even though it is closer to its star than mercury is to the sun, the star is cool enough that the surface temperature of the planet would allow the presence of liquid water, that is, it lies in the “Goldilocks” region. The study of this planet is just beginning and of course there will be an intense search for the possible presence of alien life. 

Incidentally, the Alpha Centauri system is the planned target of the “StarShot” project of Steven Hawking, Freeman Dyson and others which will involve large numbers of very small space craft (nano-crafts) that will be powered by meter-sized “LightSails” only a few hundred atoms thick driven by 100 gigawatt lasers on earth to 20% of the speed of light, allowing the 4.37 light years flight to be accomplished in 20 years. The data obtained would take 4 years to return to earth. 

This initially has the appearance of insanity, but  the list of experts is  very impressive and the Director will be Pete Worden,  the ex-director of Ames Research Laboratory.

And of course Hawking will make sure that the spacecraft do  not have a return address, so as to avoid the possibility that the aliens are intentionally or non-intentionally malevolent.

Blog Archive

Total Pageviews